Background: Curcumin with the scientific name of diferuloylmethane, is the main component of turmeric (curcuma longa) that has anti-cancer properties such as inhibition of cell proliferation and apoptosis activation. However, its poor absorption and low stability in the body, has limited its pharmaceutical application. The aim of current study, is the evaluation of apoptotic potential of dendrosomal nano-curcumin compared to void curcumin. Materials and Methods: Gastric cancer cell lines (AGS) were treated with 10, 20, 30 µΜ of dendrosomal nano-curcumin at intervals of 24 ad 48 h. Then, the quantitative expression of genes Bax, Bcl2 and B2m as internal control were evaluated by Real Time PCR. Results: Dendrosomal nano-curcumin relatively downregulated the expression of anti-apoptotic Bcl2 gene and meaningfully upregulated the expression of pro-apoptotic BAX gene in a time and dose dependent manner. Therfore, the relative expression of BAX/Bcl2 showed a meaningful increase in concentration of 30 µΜ and 48 hours compared to void curcumin. Conclusion: The results show that the death of cancerous cells treated with nano-curcumin is due to the increase in expression ratio of BAX/Bcl2 and apoptosis that beside our previous reports, strengthen the therapeutic potential of this new nano compound of curcumin.