Background: As a serious social problem in Iran that leads to many social damages and deviations, Addiction requires primary and secondary preventions. Therefore, present study has been conducted with the aim of assessing primary prevention approaches and relapse prevention from the view of patient admitted to treatment center in Ahvaz during 2012- 2013. Materials and Methods: In this cross-sectional descriptive research, 200 of addicts referred to 8 treatments centers were selected by random- cluster sampling in a six month period. Data were collected by structured interviews and a 3 part researcher designed questionnaire (included demographic data, primary prevention approaches and relapse prevention) and analyzed with SPSS19. Results: The mean age of participants in the research was 32.19 + 9.40 years, the mean age of onset for drug abus was 20. 7 + 7.37 years and the mean of addiction was 10.84 + 8.30. In the field of primary prevention approaches, familial, educational, social and economic approaches and in the field of relapse prevention, educational, familial and socioeconomic approaches were respectively as the most important approaches from patient perspective. Conclusion: According to achieved results, in all programs of primary and relapse prevention of addiction, in addition to considering individual approaches, familial, educational, social and economic approaches should be included with regard to their importance to achieve the most efficacy.