نشریه علمی پژوهشی طب انتظامی Journal of Police Medicine
Volume 14, Issue 1 (2025)
J Police Med 2025, 14(1) |
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Ethics code: IR.IAU.ARAK.REC.1404.199
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Rajabi M, Mohajerani H R, Roozbahani M, Goodarzi B. The effect of donor physical activity on the therapeutic potential of fecal microbiota transplantation against oxidative stress-induced damage.. J Police Med 2025; 14 (1) : e8
URL: http://jpmed.ir/article-1-1327-en.html
URL: http://jpmed.ir/article-1-1327-en.html
1- Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran, Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2- Islamic Azad University, Science and Research Branch, Tehran ,mohajeranihr@gmail.com
3- Assistant Professor, Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran, Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2- Islamic Azad University, Science and Research Branch, Tehran ,
3- Assistant Professor, Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran, Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran
English Extended Abstract: (851 Views)
AIMS: This study investigates the effects of fecal microbiota transplantation (FMT) from exercise-trained donors and aerobic exercise on oxidative stress in C57 male mice subjected to chronic unpredictable mild stress (CUMS).
MATERIALS AND METHODS: Four groups of mice (n=8) were studied: INTACT (no intervention), CONTROL (CUMS with saline solution), N-E-FMT (CUMS with FMT from sedentary donors), and E-FMT (CUMS with FMT from exercise-trained donors). Total serum antioxidant capacity (TAC) was measured to assess oxidative stress.
FINDINGS: The control group showed a significant decrease in TAC compared to the INTACT group (p≤0.0001), confirming stress-induced oxidative damage. The E-FMT group showed a significant increase in TAC compared to the control group (p≤0.05), indicating an increase in antioxidant capacity, while N-E-FMT showed no significant improvement.
CONCLUSION: These findings indicate that FMT from donors under exercise conditions, combined with aerobic exercise, effectively reduces oxidative stress, highlighting the importance of the donor’s physical activity in the effectiveness of FMT. This study highlights the therapeutic potential of FMT under exercise conditions for stress-related oxidative damage and calls for further research into the underlying microbial mechanisms.
MATERIALS AND METHODS: Four groups of mice (n=8) were studied: INTACT (no intervention), CONTROL (CUMS with saline solution), N-E-FMT (CUMS with FMT from sedentary donors), and E-FMT (CUMS with FMT from exercise-trained donors). Total serum antioxidant capacity (TAC) was measured to assess oxidative stress.
FINDINGS: The control group showed a significant decrease in TAC compared to the INTACT group (p≤0.0001), confirming stress-induced oxidative damage. The E-FMT group showed a significant increase in TAC compared to the control group (p≤0.05), indicating an increase in antioxidant capacity, while N-E-FMT showed no significant improvement.
CONCLUSION: These findings indicate that FMT from donors under exercise conditions, combined with aerobic exercise, effectively reduces oxidative stress, highlighting the importance of the donor’s physical activity in the effectiveness of FMT. This study highlights the therapeutic potential of FMT under exercise conditions for stress-related oxidative damage and calls for further research into the underlying microbial mechanisms.
Article number: e8
Article Type: Original Research |
Subject:
Police Health
Received: 2024/04/3 | Accepted: 2024/12/25 | Published: 2025/03/16
Received: 2024/04/3 | Accepted: 2024/12/25 | Published: 2025/03/16
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