نشریه علمی پژوهشی طب انتظامی Journal of Police Medicine
Volume 14, Issue 1 (2025)
J Police Med 2025, 14(1) |
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Ethics code: IR.IAU.ARAK.REC.1404.199
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Rajabi M, Mohajerani H R, Roozbahani M, Goodarzi B. The effect of donor physical activity on the therapeutic potential of fecal microbiota transplantation against oxidative stress-induced damage.. J Police Med 2025; 14 (1) : e8
URL: http://jpmed.ir/article-1-1327-en.html
URL: http://jpmed.ir/article-1-1327-en.html
1- Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran, Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2- Islamic Azad University, Science and Research Branch, Tehran ,mohajeranihr@gmail.com
3- Assistant Professor, Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran, Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2- Islamic Azad University, Science and Research Branch, Tehran ,
3- Assistant Professor, Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran, Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran
English Extended Abstract: (9 Views)
Aims: This study investigates the effects of fecal microbiota transplantation (FMT) from exercise-trained donors and aerobic exercise on oxidative stress in male C57 mice exposed to chronic unpredictable mild stress (CUMS).
Materials and Methods: Four groups of mice (n=8) were studied: INTACT (no intervention), CONTROL (CUMS with saline), N-E-FMT (CUMS with FMT from sedentary donors), and E-FMT (CUMS with FMT from exercise-trained donors). Total antioxidant capacity (TAC) in serum was measured to assess oxidative stress.
Findings: The CONTROL group showed a significant decrease in TAC compared to the INTACT group (P≤0.0001), confirming stress-induced oxidative damage. The E-FMT group exhibited a significant increase in TAC compared to the CONTROL group (P≤0.05), indicating enhanced antioxidant capacity, whereas N-E-FMT showed no significant improvement.
Conclusion: These findings suggest that FMT from exercise-conditioned donors, combined with aerobic training, effectively attenuates oxidative stress and highlight the importance of donor physical activity in FMT efficacy. This study underscores the therapeutic potential of exercise-conditioned FMT for stress-related oxidative damage and calls for further investigation into the underlying microbial mechanisms.
Materials and Methods: Four groups of mice (n=8) were studied: INTACT (no intervention), CONTROL (CUMS with saline), N-E-FMT (CUMS with FMT from sedentary donors), and E-FMT (CUMS with FMT from exercise-trained donors). Total antioxidant capacity (TAC) in serum was measured to assess oxidative stress.
Findings: The CONTROL group showed a significant decrease in TAC compared to the INTACT group (P≤0.0001), confirming stress-induced oxidative damage. The E-FMT group exhibited a significant increase in TAC compared to the CONTROL group (P≤0.05), indicating enhanced antioxidant capacity, whereas N-E-FMT showed no significant improvement.
Conclusion: These findings suggest that FMT from exercise-conditioned donors, combined with aerobic training, effectively attenuates oxidative stress and highlight the importance of donor physical activity in FMT efficacy. This study underscores the therapeutic potential of exercise-conditioned FMT for stress-related oxidative damage and calls for further investigation into the underlying microbial mechanisms.
Article number: e8
Keywords: Fecal Microbiota Transplantation (FMT), Oxidative Stress, Chronic Unpredictable Mild Stress (CUMS), Aerobic Exercise, Total Antioxidant Capacity (TAC).
Article Type: Original Research |
Subject:
Police Health
Received: 2025/09/18 | Accepted: 2026/06/22 | Published: 2026/07/25
Received: 2025/09/18 | Accepted: 2026/06/22 | Published: 2026/07/25
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