نشریه علمی پژوهشی طب انتظامی Journal of Police Medicine
Volume 13, Issue 1 (2024)
J Police Med 2024, 13(1) |
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Ethics code: 302322011003
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Zeinoddini M, Mardashti Z, Jamal Mohammadi F. A review of the new diagnostic kits design based on CRISPR. J Police Med 2024; 13 (1)
URL: http://jpmed.ir/article-1-1285-en.html
URL: http://jpmed.ir/article-1-1285-en.html
1- Department of Science and Biotechnology , zeinoddini@modares.ac.ir
2- Department of Science and Biotechnology, Malek Ashtar University of Technology
2- Department of Science and Biotechnology, Malek Ashtar University of Technology
English Extended Abstract: (675 Views)
Aims: CRISPR is one of the most important gene editing tools that has been developed rapidly in biotechnology. Apart from the application of CRISPR in gene editing, this technique can be used to design new and accurate diagnostic methods. The aim of this study is to introduce the diagnostic applications of CRISPR and to examine the unique futures of this technology.
Methods: This research was conducted from spring to winter 2024 by reviewing and interpreting authoritative articles and related scientific books. The keywords searched were generally related to CRISPR technology and included gene editing, cas, CRISPR based biosensor, and CRISPR-Chip in Google Scholar, NCBI, PubMet, and other authoritative databases.
Findings: The coronavirus pandemic has led to the development of diagnostic methods that can quickly and accurately detect the presence or absence of a pathogen. The design of portable CRISPR kits, while being simple to operate and not requiring the participation of specialized individuals, can be a suitable option and be beneficial to society in terms of money and time. CRISPR microarrays or CRISPR–Chips are the latest diagnostic kits that are capable of identifying the target at femtomolar detection levels without the need for genome amplification. This method can also be used in criminal identification.
Conclusion: In the fields of medicine, criminal identification, biosecurity and food security, the development of diagnostic methods with high sensitivity and specificity, low cost, rapid response and simultaneous detection of multiple targets is very necessary. The CRISPR–Chip is considered one of the promising methods for the development of new diagnostic kits for the identification of biological samples and genome pathogens.
Methods: This research was conducted from spring to winter 2024 by reviewing and interpreting authoritative articles and related scientific books. The keywords searched were generally related to CRISPR technology and included gene editing, cas, CRISPR based biosensor, and CRISPR-Chip in Google Scholar, NCBI, PubMet, and other authoritative databases.
Findings: The coronavirus pandemic has led to the development of diagnostic methods that can quickly and accurately detect the presence or absence of a pathogen. The design of portable CRISPR kits, while being simple to operate and not requiring the participation of specialized individuals, can be a suitable option and be beneficial to society in terms of money and time. CRISPR microarrays or CRISPR–Chips are the latest diagnostic kits that are capable of identifying the target at femtomolar detection levels without the need for genome amplification. This method can also be used in criminal identification.
Conclusion: In the fields of medicine, criminal identification, biosecurity and food security, the development of diagnostic methods with high sensitivity and specificity, low cost, rapid response and simultaneous detection of multiple targets is very necessary. The CRISPR–Chip is considered one of the promising methods for the development of new diagnostic kits for the identification of biological samples and genome pathogens.
Article Type: Systematic Review |
Subject:
Police Medicine Related Technologies
Received: 2025/01/4 | Accepted: 2025/02/13 | Published: 2024/04/21
Received: 2025/01/4 | Accepted: 2025/02/13 | Published: 2024/04/21
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