نشریه علمی پژوهشی طب انتظامی Journal of Police Medicine
Volume 7, Issue 4 (2018)
J Police Med 2018, 7(4) |
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papi M, nezhadali M, alinezhad M. Evaluation of serum visfatin level in obese subjects and its relationship with Insulin and Body Mass Index in Persons Referred to Military Hospital in Tehran. J Police Med 2018; 7 (4)
URL: http://jpmed.ir/article-1-722-en.html
URL: http://jpmed.ir/article-1-722-en.html
1- Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran
2- Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran ,ma_nejadali@yahoo.com
3- Faculty of medical, Tehran Medical Branch, .Islamic Azad University, Tehran, Iran
2- Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran ,
3- Faculty of medical, Tehran Medical Branch, .Islamic Azad University, Tehran, Iran
English Extended Abstract: (2339 Views)
Aims Obesity is a major public health problem in developed and even in developing countries worldwide. Visfatin, protein secreted by visceral adipose tissue.Visfatin seems to modulate insulin sensitivity and appear to play an important role in the pathogenesis of insulin resistance, diabetes, dyslipidemia and obesity .The aim of this study was to determine visfatin serum concentration in overweight/obese subjects and its association with obesity and insulin resistance.
Methods This case-control study was performed on 93 individuals with BMI≥25 as case group, and 80 individuals with BMI<25 as control group in Military Hospital in Tehran. Anthropometric measures and metabolic parameters were obtained. Fasting insulin and visfatin were measured using the Mercodia ELISA kit (Mercodia Company, Sweden). Data were analyzed using SPSS software. (Version 19).
Findings Plasma visfatin levels fasting glucose and insulin and HOMA-IR,were significantly higher in obese subjects compared to control group (p<0/05). Also, there was a significant correlation between serum visfatin level and body mass index (BMI)and fasting blood glucose in group with BMI≥25. No correlation was found between visfatin and HOMA-IR (p>0.05) and insulin (p=0.05).
Conclusion: There may be a possible role of visfatin in the Pathophysiology obesity. Visfatin was associated with body mass index and impaired metabolism glucose, but not with insulin resistance.
Article Type: Original Research |
Subject:
Police Health
Received: 2018/07/1 | Accepted: 2018/09/11 | Published: 2018/10/7
Received: 2018/07/1 | Accepted: 2018/09/11 | Published: 2018/10/7
English Expanded Abstract [HTML 18 KB] (99 Download)
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