Background: Farnesiferol C, a sesquiterpene coumarin, is one of the biologically active compounds extracted from the roots of Ferula Szowitziana and shows different anti-cancer properties such as anti-proliferation and apoptosis induction. However, the solubility and bioavailability of this phytochemical is poor in vivo and in vitro. Denderosome nanoparticles could improve the solubility of Farnesiferol C and hence its anti-cancer properties. The aim of current study was based on improving the solubility of Farnesiferol C by taking advantage of dendrosome nanoparticles and subsequently evaluating its cytotoxic effect against gastric adenocarcinoma. Materials and Methods: The cytotoxic effect of dendrosomal Farnesiferol C was investigated on AGS cells by MTT assay. The cells were then incubated with fresh medium containing serial concentrations of Farnesiferol C (0 to 150 μM) in the form of dendrosomal and void Farnesiferol C for 24 and 48h. Afterward, the toxicity of this botanic compound and its IC50 were measured. Data were analyzed by regression & t-test. Results: The data illustrate a reverse and significant relation between dendrosomal Farnesiferol C and void Farnesiferol C variables (P<0.001). Also, cytotoxic effect of dnedorsomal Farnesiferol C on AGS cells was much more than free Farnesiferol C and affected in low concentrations (P<0.05). Conclusion: The results showed that dendrosomal Farnesiferol C could be an appropriate and safe anti-cancer phytochemical that demands molecular evaluation of its anti-tumor effect on different cancerous and normal cell lines.