Background: Investigating and understanding psychological factors related to Symptoms of Borderline Personality in people with borderline personality disorder can be an important step towards identifying the causes of it. Thus, the current study was conducted in order to investigate the role of distress tolerance and self-compassion in predicting Symptoms of Borderline Personality in people with borderline personality disorder. Materials and Methods: This descriptive study was conducted within correlation and prediction method. All men with borderline personality disorder, referring to the psychiatric section of Imam Sajjad (AS) Hospital of Tehran in the first half of 1393 (April-September, 2014), compromised the statistical population of current study. 94 people were selected from this population by convenience sampling and were asked to respond to questionnaires of Symptoms of Borderline Personality, distress tolerance and self-compassion. Then, data were analyzed via Pearson correlation test and multiple regression analysis using SPSS version 18. Results: The results showed that the Symptoms of Borderline Personality have negative correlation with total score of distress tolerance (r=-0.40 p<0.001), and components of regulation (r=-0.41 p<0.001), evaluation (r=-0.33 p<0.001), and total score of self-compassion (r=-0.56 p<0.001), and components of self-kindness (r=-0.42 p<0.001), common humanity (r=-0.38 p<0.001), and mindfulness (r=-0.35 p<0. 001), but have positive correlation with self-judgment (r=0.48 p<0.001), and isolation (r=0.41 p<0.001). Also the results of regression analysis showed that 20% of variance of Symptoms of Borderline Personality was explained by distress tolerance (F=5.44 p<0.001) and 40% variance of it was explained by self-compassion (F=8.99 p<0.001). Conclusion: These results showed that distress intolerance and low self-compassion can play roles in Symptoms of Borderline Personality in people with borderline personality disorder.