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Volume 5, Issue 2 (2016)                   J Police Med 2016, 5(2) | Back to browse issues page


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Saebnia N, Sadeghizadeh M, Dehghan Esmatabadi M J, Movahedi motlagh F. The main factors involved in the recurrence of colorectal cancer and therapeutic methods against them. J Police Med 2016; 5 (2)
URL: http://jpmed.ir/article-1-451-en.html
1- 1Ms.c, Department of Genetics, School of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
2- Professor, Department of Genetics, School of Biological Sciences, Tarbiat Modares University, Tehran, Iran. , sadeghma@modares.ac.ir
3- 3Ph.D Student, Department of Genetics, School of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
4- 4Ms.c, Department of Cellular and Molecular Biology, National Institute of Genetic
English Extended Abstract:   (3502 Views)

Colorectal cancer (CRC) is the third most common cancer in the world with a mortality rate of approximately 50% of patients. In spite of developments in therapeutic methods, surgical resection is only most effective therapeutic way in most tumors. However, ~30-40% of patients show recurrence after surgery. So, a huge need to finding of main CRC recurrence causes is feeling. In this review article, we attempt to study some of the most important CRC recurrence causes including cancer stem cells, miR-520g and its role in drug resistance, circulating tumor cells, TGF-β signaling pathway, postoperative intra-abdominal infection, catecholamins and prostaglandins and COX2 pathway and to present some combat strategies to these factors.

 

Full-Text [PDF 881 kb]   (2229 Downloads)    
Article Type: Descriptive & Survey |
Received: 2016/01/9 | Accepted: 2016/07/4 | Published: 2016/07/4

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