Background: The present study was designed and carried out aiming to evaluate the effects of local Dexmedetomidine on propofol consumption in candidate patients for fiberoptic nasotracheal awake intubation.

Materials and Methods: Candidate patients were randomly divided into two groups including local Dexmedetomidine group and control group. Local anesthesia using lidocaine was performed in all patients followed by injection of Dexmedetomidine in local Dexmedetomidine group. After performing the intubation, propofol infusion was used to keep the patients on considered cerebral state index (CSI). Hemodynamic parameters and arterial blood O2 saturation (SpO2) were monitored. Propofol consumption for assessing CSI about 65-75 was measured.

Results: A total of 64 patients with the mean age of 44.9±13.9 were evaluated (54.7% female). Baseline hemodynamic parameters and SpO2 were not significantly different between two groups. There is significant statistical difference in propofol consumption between local Dexmedetomidine group in compare with control (p<0.001).

Conclusion: It is likely that local Dexmedetomidine can be useful with the aim of propofol dose saving during awake intubation via fiberoptic.