Background: The aim of this study is investigating the effect of aerobic training on cardiac expression of mir-126 in normal and diabetic rats.

Materials and Methods: 35 Rats divided to two categories, diabetic and non-diabetics rats. Then each category of diabetic and non diabetic animals will be divided to two groups: under training and non-training. Cardiac muscle will be removed and immediately placed into liquid nitrogen. Cardiac expression of mir-126 is investigated in rat cardiac muscle with method of Real-time PCR. For data analysis, One Way ANOVA and Tukey test will be used to find differences between groups

Results: The study results showed diabetes significantly decreased cardiac expression of mir126 and 8 weeks of aerobic training significantly increased cardiac expression of mir126 in healthy and diabetic rats.

Conclusion: Thus, it seems aerobic training can via angiogenic path incurred diabetes improvement. Also, as for results of yielded from this study and kindle regulatory processes by mir126 that via aerobic training be impressed, it is get worth strategy that it can lead in diabetes on development of new therapy methods.