Colorectal cancer (CRC) is the third most common cancer in the world with a mortality rate of approximately 50% of patients. In spite of developments in therapeutic methods, surgical resection is only most effective therapeutic way in most tumors. However, ~30-40% of patients show recurrence after surgery. So, a huge need to finding of main CRC recurrence causes is feeling. In this review article, we attempt to study some of the most important CRC recurrence causes including cancer stem cells, miR-520g and its role in drug resistance, circulating tumor cells, TGF-β signaling pathway, postoperative intra-abdominal infection, catecholamins and prostaglandins and COX2 pathway and to present some combat strategies to these factors.