Background: methamphetamine is a Nervous system stimulant that are more widely abuse around the world such as Iran as well as abuse this is dramatically increased. Because of the simplicity of the synthesis methods, this substance is widely produced in clandestine places. Therefore, Identifying salt profiling of discovered methamphetamine could help identifying and tracking these places, lead to destroy the distribution networks ,and prevent the use of this substance. Identifying the type of methamphetamine salt is a part of the whole methamphetamine profiling process which is reviewed in this study. Materials and Methods: In this study, all 40 discovered crystal methamphetamine in 2014 by antinarcotics police of Islamic Republic of Iran were analyzed through Precipitation method to determine the salt forms of the samples. Results: The results show that all the samples contain the chloride salt and the other salts were not found in the examined samples. Conclusion: Salt profiling of seized methamphetamines show that all samples were contain only the hydrochloride salt. This finding is similar to the results of the previous study were done in 2010. Since pseudoephedrine is the precursor of the methamphetamine synthesis in Iran, probably, the manufacturers have used the East Asian method of methamphetamine production. The results of these studies, confirm the importance of stopping the production of solid pseudoephedrine containing pharmaceuticals in Iran. Science, the impurities of the liquid pseudoephedrine containing pharmaceuticals were found in some samples, the decision to stop production of these preparations may become necessary.